Monday, September 30, 2024

What’s all this business about lying wine bottles on their side?

There are lots of guidelines regarding the purchase, storage and consumption of wine. Some people see these protocols as rules produced by wine snobs, because most of them don’t apply to beers, spirits or RTDs; and it has been suggested that this is part of the reason why younger people are not interested in wine. Indeed, only some of these guidelines may be so useful, as I will discuss today.

For example, opening an old wine bottle quite some time before you intend drinking its contents really can get the wine to start releasing its inherent aromas — so-called “opening up” (for an example: Wine decanting: give wines some air, or Give that old wine a chance before you tip it down the drain). Similarly, being careful about the sediment in an old bottle of red wine can make your guests be more polite — decanting the wine works, but so does pouring carefully when serving (in both cases, after standing the bottle upright for a while).

Wall mounted wine storage

However, there is one guideline that may be more questionable. This is the suggestion that wine bottles should be stored lying on their side. Now, obviously this does not apply to the vast majority of the wine produced in the world today, because that wine is drunk not very long after it is purchased (or even stolen, I guess). We are talking here about wine that is being stored for some lengthy time. Also, it does not apply to wines being stored in a plastic bag inside a cardboard box. *

The MasterClass list of the storage guidelines for wine looks like this (7 tips for storing wine at home):
  • Store wine at the proper temperature
  • Store wine bottles horizontally
  • Protect wine from light and vibration
  • Store wine at the proper humidity
  • Store wine in a wine fridge, not a regular fridge
  • Serve wine at the proper temperature
  • Store open bottles of wine properly
You don’t see this sort of list for beers, spirits or RTDs! Anyway, we are looking in this blog post at item number two.

Ancient bottles being stored

Let’s get one thing clear at the start, storing wines for any length of time does definitely have an affect on the wine. A formal review (Bottle aging and storage of wines: a review) notes:
Summarizing collected data, bottle aging and storage of wine is an important albeit complex and sensible process that greatly influences the features of the final product. During storage, deep changes in aroma, color stability, appearance, and mouthfeel take place and define the quality of wine, which, in turn, impacts consumer preference and appreciation.
The question, though, is: which of these things matter the most?

There appears to be only one formal research publication on the topic, from 2008 in Australia (The impact of closure type and storage conditions on the composition, colour and flavour properties of a Riesling and a wooded Chardonnay wine during five years’ storage), and it covers only two wines, both white. It concluded: “The bottle orientation during storage under the conditions of this study had little effect on the composition and sensory properties of the wines examined.”

So, 5 years of data on two wines was not supportive. Similarly, a researcher at a cork manufacturer has claimed: “The cork will never dry out with almost 100% humidity in the headspace, so it is a myth that you need to store a bottle on its side” (Storing wine on its side is nonsense, says scientist). Sadly, many of the commenters on that article disagreed with the author, some citing their experiences with storing wines upright over extensive periods of time — the corks did shrink.

So, one of the most common reasons suggested for lying a wine bottle down is keeping the cork wet. However, not everyone agrees with this, as discussed by Chris Shanahan concerning screwcaps (Cork vs screwcap Tyrrell’s Vat 1 Hunter Semillon 1998):
We drew a decent cork, and as a result enjoyed two amazing but notably different old whites. Most of the group preferred the dazzling, fresh-but-aged screwcap version. But a few favoured the deeper colour and mellow flavours of the cork-sealed wine.
One tasting of two bottles reveals little about the relevant merits of cork and screwcap. A good cork works. But earlier formal trials, and my own experience, show you might need to open several bottles to find a good cork, where every screwcap does the job reliably.
There are many types of stoppers

Well, all of this means that most commentary on bottle storage is based on personal anecdotes; but you may like to play it safe and lie the bottles down (Some wine pros say bottles don't need to be stored on their sides. Is that true?). However, most people do not store their wine long enough for the orientation to make the slightest difference (especially if the wine is in a can: In praise of canned wine).

On the other hand, there seems to be little argument that the temperature of storage makes a big difference, as suggested by several formal experiments:
To me, however, the bottom line is that the average wine lover is not someone with encyclopaedic knowledge. Instead, it is this (7 tips for storing wine at home):
Drinking wine is about people not about wine. Sure, we have lots of information and guidelines about what to do, but without my wife, relatives and friends beside me when I open the bottle, I don't give a hoot about those details. I store my wine in the “correct” manner (lying down in a cool dark place) for the expert-suggested period of time; and I therefore expect the wine to be in good condition when I open the bottle. But I am not thinking about technical details when I open it — I am anticipating how much I am going to enjoy the contents, along with my meal.
All of the details are rightly seen as esoteric, even snobbish, by 99% of wine drinkers.
This important point is all too often missing, as formally suggested by linguist Dariusz Galasinski (A better way to communicate wine):
Talking about wine can mean different things. All too often I kept hearing about residual sugar, tanks, oak, and so on. All could have been done via email. Yes, the technicalities were sometimes accompanied by the producer’s ‘wine philosophy’, but, more often than not, it sounded much better than it was.
But sometimes I heard stories of people engaged in the production. What is it like to collect grapes on the steep slopes of the Mosel? What is it like to see mildew eating up the grapes in Chablis? Or about how the producer’s neighbours helped in the winery and eventually drank the wine. At such tastings, we drank wine made by a real person, from grapes collected by real people, whose cousins, aunts and grandparents were also involved in the hard work. Wine became social and dialogic. Well, wine became ours.
The biggest benefit of wine is that it makes us happy. It was on this basis that I produced last week’s post: Interesting wine quotes from famous people.



* Remember, in the modern world we are supposed to be minimizing our use of plastics!

Monday, September 23, 2024

Interesting wine quotes from famous people

The most famous quote about wine is probably this Latin one: “In vino veritas.” It is apparently referenced several times in antiquity. Pliny the Elder (23—79 AD) has an early allusion, usually translated as: “In wine, there is truth, and in friendship, there is joy”. Plato (427—348 BC) has an even earlier reference, usually translated as: “There is truth in wine and children.”

As a break from my usual type of blog post, it seems worthwhile to collate here other invaluable wine quotations from over the millennia, ones that are attributed to a specific person, rather than simply to the ubiquitous “Anonymous”. So, here are three dozen of them, with their acknowledged (usually well-known) authors, in time order.

Live longer

  • “Wine can of their wits the wise beguile, make the sage frolic, and the serious smile.” ― Homer (8th century BC)
  • “Whenever a man is tired, wine is a great restorer of strength.” ― Homer
  • “Where there is no wine there is no love.” ― Euripides (480—406 BC)
  • “Nothing more excellent or valuable than wine was ever granted by the gods to man.” ― Plato (427—348 BC)
  • “When a man drinks wine at dinner, he begins to be better pleased with himself.” ― Plato
  • “Quickly, bring me a beaker of wine, so that I may wet my mind and say something clever.” ― Aristophanes (446—386 BC)
  • “What I like to drink most is wine that belongs to others.” — Diogenes (4th century BC)
  • “Wine brings to light the hidden secrets of the soul.” ― Horace (65—8 BC)
  • “No poem was ever written by a drinker of water.” ― Horace
  • “Wine is life.” ― Gaius Petronius Arbiter (27—66 AD)
  • “Sorrow can be alleviated by good sleep, a bath, and a glass of wine.” — Thomas Aquinas (1225—1274)
  • “The discovery of a good wine is increasingly better for mankind than the discovery of a new star.” ― Leonardo Da Vinci (1452—1519)
  • “Beer is made by men, wine by God.” ― Martin Luther (1483—1546)
  • “Age appears best in four things: old wood to burn, old wine to drink, old friends to trust, and old authors to read.” ― Francis Bacon (1561—1626)
  • “Wine is sunlight, held together by water.” ― Galileo Galilei (1564—1642)
  • “The discovery of a wine is of greater moment than the discovery of a constellation. The universe is too full of stars.” ― Benjamin Franklin (1706—1790)
  • “Wine makes daily living easier, less hurried, with fewer tensions and more tolerance.” ― Benjamin Franklin
  • “In wine there is wisdom, in beer there is freedom, in water there is bacteria.” ― Benjamin Franklin
  • “Wine brightens the life and thinking of anyone.” ― Thomas Jefferson (1743—1826)
  • “In nothing have the habits of the palate more decisive influence than in our relish of wines.” — Thomas Jefferson
  • “Wine rejoices the heart of man, and joy is the mother of all virtues.” ― Johann Wolfgang von Goethe (1749—1832)
  • “Life is too short to drink bad wine.” ― Johann Wolfgang von Goethe
  • “A meal without wine is like a day without sun[shine].” ― Jean Anthelme Brillat−Savarin (1755—1826)
  • “In victory, you deserve Champagne. In defeat you need it.” ― Napoleon Bonaparte (1769—1821)
  • “Nothing makes the future look so rosy as to contemplate it through a glass of Chambertin.” ― Napoleon Bonaparte
  • “God made water, but man made wine.” ― Victor Hugo (1802—1885)
  • “Wine is life. It's the union of the earth with the sun; it’s the essence of time captured in a bottle.” ― Victor Hugo
  • “Give me wine to wash me clean of the weather-stains of cares.” ― Ralph Waldo Emerson (1803—1882)
  • “I rather like bad wine; one gets so bored with good wine.” ― Benjamin Disraeli (1804—1881)
  • “Be careful to trust a person who does not like wine.” ― Karl Marx (1818—1883)
  • “A bottle of wine contains more philosophy than all the books in the world.” ― Louis Pasteur (1822—1895)
  • “Wine can be considered with good reason as the most healthful and hygienic of all beverages.” ― Louis Pasteur
  • “Wine is bottled poetry.” ― Robert Louis Stevenson (1850—1894)
  • “I will drink milk when cows eat grape.” ― Henri de Toulouse−Lautrec (1864—1901)
  • “Penicillin cures, but wine makes people happy.” ― Alexander Fleming (1881—1955)
  • “Men are like wine — some turn to vinegar, but the best improve with age.” ― Angelo Giuseppe Roncalli (Pope John XXIII) (1881—1963)
  • “My only regret in life is that I did not drink more wine.” ― Ernest Hemingway (1899—1961)
  • “I drink to make other people more interesting.” ― Ernest Hemingway
  • “I cook with wine. Sometimes I even add it to the food.” ― usually attributed to either W.C. Fields (1880—1946) or Julia Child (1912—2004), neither of whom seems to have actually said it.

Monday, September 16, 2024

There is no single optimum for the amount of alcohol to be consumed by people

I received a (free) book in the mail the other day, which reminded me of my scientific past. I have mentioned in recent posts that I used to teach university students (studying biological science) about experimental design; and in the blog posts I have recently applied this knowledge to experiments concerning alcohol and health (eg. Why alcohol experiments are problematic).

Well, for my scientific research, one of the things I worked on was biological networks. You have all heard about Charles Darwin and the “Tree of Life”, the idea that all organisms are descended from ancestors, with modification. That is, a family tree (of people) becomes a bigger, and older, tree of all organisms, if we go back far enough in time. Well, this is only partly true, because there are all sorts of genetic inter-connections among those branches, so that it is actually a “Network of Life”.

I was one of the early people championing this idea, back 20 years ago. The book that I received is called: The Network of Life: a New View of Evolution, by David P. Mindell (June 2024. Princeton University Press). So, let’s look at this book here, and some ideas it covers related to the effects of alcohol on people. I need to present some background first, and then move on to the alcohol effects.

Book cover

The network idea is that species share genetic material, via a process called horizontal evolution, so that evolution is actually a web of shared genealogy, instead of just from ancestor to descendant. Species are thus more interconnected than previously thought. Life is not a tree but a network (see the next figure). The complex example of our own history (Homo sapiens) is shown in the network diagram below (taken from Mindell’s book).

To establish my bona fides, at the end of this post I have listed a few of my professional publications related to this topic of evolutionary networks, including the introductory book that I wrote (Introduction to Phylogenetic Networks). My previous blog (2012—2020) was also on this topic: The Genealogical World of Phylogenetic Networks. *

My connection to this new book (and why I got a free copy) is indicated in the Preface: “I am enormously grateful to colleagues who read sections of the full draft of the book. Their insights, patience, and thoughtful commentary improved the book a great deal. This includes Ford Doolittle, Axel Meyer, David Morrison, Greg Gibson, James McInerney, Maureen Kearney, Mary Ellen Hannibal, Peter Alpert, Matt Kane, Jack Sites, Ed Braun, and Dan Graur.” That’s quite a list, but I made it to third! [I read the draft way back in 2022.]

A phylogenetic tree
A phylogenetic network

For our main purpose here, in looking at alcohol and people, the author notes that:
“The Network of Life describes the drivers of horizontal evolution — inter–breeding and genetic recombination, the merger of species, horizontal gene transfer, and co–evolution. The network view of evolution that emerges supports a new symbiotic theory of health, which holds that the future health of humans, other species, and our shared environments depends on evolution and adaptations across life’s network.”
As the author points out, the old “Germ Theory of Disease” focuses on human disease itself, whereas the new “Symbiotic Theory of Disease” focuses on human and environmental health. That is, human diseases stem from infection with certain organisms, whereas human health actually stems from the capacity to recover from disease and injury, and to adapt to change over time. So, in the latter the focus is on both short-term and longer-term relationships of other organisms in human and environmental health.

Now, the author mainly restricts himself to the complex network that exists between any given species and the disease–causing organisms that surround and inhabit it. However, I wish to look here at the medical status of humans and their interaction with their environment. Obviously, in this blog, the aspect of the environment under discussion will be the alcohol that the people transfer from their environment into their own bodies.

The complex history of Homo sapiens

The basic idea is that there is no static optimum for the nature of the interaction (alcohol in this case) under discussion, because the relationships are evolving in both time and space. The World Health Organization’s declaration (January 2023) that there is “no safe level” of alcohol consumption (that does not affect health) makes little biological sense.

The book’s author notes:
“What do we mean by health? Human health is often taken to be the the mere absence of illness. That view may work on a short time scale. But over longer time frames, health and sickness are not mutually exclusive conditions. Reacting to a flu virus with a fever, aching joints, nausea, and swollen lymph glands, the classic signs of sickness, is a sign of good health, as manifest by a healthy immune system. Sickness and health co–exist, and a long life includes many periods of injury and sickness, followed by recoveries ... Because health and sickness vary over time, there is no narrow or statistically defined normal or abnormal state of these conditions. Environmental health is similarly dynamic. At all levels, health is more about resilience, adaptability to trauma, and persistence over time than it is about absence of sickness.”
So, the idea that there could be a pre-specified amount of alcohol that humans can safely consume, medically, is naive. The amount that we could safely consume at one time in our life will not be the same as at another time. We adapt through time, based on what has already happened to us during our life — we meet our own medical needs over time by being resilient, and adjusting to change. There is no such thing as “normal” — it changes through time for each of us.

Furthermore, our body is a system of interactions among many components (organs, chemicals, micro–organisms). There is much evidence that the microorganisms in our body impact our behaviour. Their chemical compounds can and do stimulate our nervous system and brain, influencing our mood and actions. So, the host behaviour is not controlled by the host’s genes alone. There is no such thing as “normal” — it changes in space, as well.

The site of the Neolithic wine

Just as importantly, the amount of alcohol that we could safely consume thousands of years ago was not the same as now, nor will the amount we consume now be the same as a thousand years in the future. The human species has a long past (there is evidence of Neolithic wine, 8,000 years ago, at the site shown above**), and we will presumably have a long future (although we may change a lot during that time). There is the intriguing idea that our species has evolved while consuming alcohol, and interfering with that consumption might actually have negative effects on us.

For example, we know that reducing some of our previous environmental exposures has correlated with the increasing prevalence of allergies (Why our allergies are getting worse), and reducing exposure to some of our previous microbes may be correlated with the increasing prevalence of auto–immune diseases (The increasing prevalence of autoimmunity and autoimmune diseases). Thus, reducing our exposure to alcohol may actually have negative effects! [So might increasing it, of course.]



Publications

Morrison, D.A. (2011) Introduction to Phylogenetic Networks. RJR Productions, Sweden. vi+216 pp. ISBN 978-91-980099-0-3. [Formally reviewed here.]

Morrison, D.A. (2005) Networks in phylogenetic analysis: new tools for population biology. International Journal for Parasitology 35: 567-582.

Morrison, D.A. (2010) Using data-display networks for exploratory data analysis in phylogenetic studies. Molecular Biology and Evolution 27: 1044-1057.

Morrison, D.A. (2013) Phylogenetic networks are fundamentally different from other kinds of biological networks. In W.J. Zhang (ed.) Network Biology: Theories, Methods and Applications (Nova Science Publishers, New York) pp. 23-68.

Bapteste, E., van Iersel, L., Janke, A., Kelchner, S., Kelk, S., McInerney, J.O., Morrison, D.A., Nakhleh, L., Steel, M., Stougie, L. and Whitfield J. (2013) Networks: expanding evolutionary thinking. Trends in Genetics 29: 439-441.



* My networks blog went for 3,187 days (or 8 years 8 months 22 days). So far, this wine blog has gone for 3,036 days (8 years 3 months 22 days). So, I’m getting there. [Tom Wark suggests that the technology for wine blog publishing became “very accessible” around 2009 — his Fermentation blog actually started in November 2004, and moved on to a new platform in January 2022.]

** The Agricultural Revolution started 12,000 years ago, and the Wheel was developed 5,500 years ago.

Monday, September 9, 2024

Why alcohol experiments are problematic

I recently published a post (Has the WHO lost its way regarding alcohol?) pointing out that what is recognized to be the best form of scientific experiment is what is called a “double-blind treatment–control” experiment (or sometimes a “randomized controlled trial”, or RCT). This procedure cannot usually be done ethically on people, and therefore no-one has ever admitted doing it in medical science. So, we will never have the best possible scientific evidence about the effects of alcohol on human health.

This does not mean that we do not have experiments about wine and health. What the scientists do is the best that they ethically can; and some of the pros and cons of this process is what I will discuss in this post. I cover several different but important topics.


What the researchers do is to follow groups of drinkers and non-drinkers through time, and see how these people get on — this is called a “descriptive” study rather than a “manipulative” one (as described above), of which there are several types as listed in the above picture. Here, we are concerned with the first one in the list, “observational”. In this type of study, health and behavior experts measure all of the consistent differences they can find between the studied people, to see what matches their patterns of their drinking and non-drinking. The results of the famous 1926 study by Raymond Pearl are shown in the next graph, as but one early example.

Also, we should ideally do all of this in such a manner that the people involved do not know which of the experimental groups they are in, and nor do the people evaluating their behavior (this is what “double blind” means). Is this actually feasible? Of course not. We can’t force people into the experimental groups, we can only ask them to volunteer to participate. That is, we rely on self–reporting of their alcohol consumption (often via detailed questionnaires filled in by the participants). Let’s look at the consequences of this now.

Here, is one useful recent discussion of how we might justifiably proceed (Causal inference about the effects of interventions from observational studies in medical journals):
Building on the extensive literature on causal inference across diverse disciplines, we suggest a framework for observational studies that aim to provide evidence about the causal effects of interventions based on 6 core questions: what is the causal question; what quantity would, if known, answer the causal question; what is the study design; what causal assumptions are being made; how can the observed data be used to answer the causal question in principle and in practice; and is a causal interpretation of the analyses tenable?

Raymond Pearl's 1926 observational study

This is all well and good, but the biggest recognized issue is how to choose the studied people. Basically, the choice should be literally random, but this is impossible. As a discussion of the problems with one example of this, we have:
In particular, people volunteer to take part in experiments, and this can never be described as “random”. Notably, people’s admissions regarding their own drinking may not be accurate (see also: Wine ratings involve both the accuracy and bias of the raters). This is discussed here:
As one specific example discussion (Reweighting UK Biobank corrects for pervasive selection bias due to volunteering):
Volunteers tend to be healthier and of higher socio-economic status than the population from which they were sampled ... Volunteer bias in all associations, as naively estimated in UKB, was substantial — in some cases so severe that unweighted estimates had the opposite sign of the association in the target population. For example, older individuals in UKB reported being in better health, in contrast to evidence from the UK Census.
So, we often end up with this rather jaundiced (but realistic) view:

The original of this cartoon hangs on my study wall

Moving on, another potential approach, to getting around the sampling problems discussed here, is to use animals as a substitute for humans (eg. mice or dogs). This generates a lot of emotional response from parts of the public, which I will not delve into here. Instead, I will focus on the actual experiments.

One useful discussion is (The flaws and human harms of animal experimentation):
Nonhuman animal (“animal”) experimentation is typically defended by arguments that it is reliable, that animals provide sufficiently good models of human biology and diseases to yield relevant information, and that, consequently, its use provides major human health benefits. I demonstrate that a growing body of scientific literature critically assessing the validity of animal experimentation generally (and animal modeling specifically) raises important concerns about its reliability and predictive value for human outcomes and for understanding human physiology ... The resulting evidence suggests that the collective harms and costs to humans from animal experimentation outweigh potential benefits and that resources would be better invested in developing human-based testing methods.
One important point is whether animal experiments actually lead to any benefit for human medical treatments. Sadly, it seems mostly not (Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications):
There is an ongoing debate about the value of animal experiments to inform medical practice, yet there are limited data on how well therapies developed in animal studies translate to humans. We aimed to assess 2 measures of translation across various biomedical fields: (1) The proportion of therapies which transition from animal studies to human application, including involved timeframes; and (2) the consistency between animal and human study results ... The overall proportion of therapies progressing from animal studies was 50% to human studies, 40% to RCTs, and 5% to regulatory approval.
Drink in moderation

I think that you can all see the bottom line here: things are not likely to get any better any time soon, regarding experiments of alcohol intake by humans. The medical scientists are doing the best that they ethically and practically can, in the real world. This, however, does not match what they would be doing in the theoretical world of scientific experiments, which is what would be the best for devising effective medical ideas.

Nevertheless, I am not the only one who has noted that there is: ‘No good evidence’ of risk from low-level alcohol consumption. Basically, the risks of one or two drinks per day are so low that they are very difficult to estimate; and drinking with meals also seems to be unproblematic (Drinking wine with meals linked to better health outcomes). Alternatively, there definitely are risks associated with heavy alcohol consumption, and people with known health problems related to alcohol may not have any safe level of consumption, as well as pregnant women. People with a family history of alcohol abuse also need to be careful.

Monday, September 2, 2024

The no- and low-alcohol conundrum

As I noted last week (Has the WHO lost its way regarding alcohol?), the World Health Organization has mistakenly taken a very negative formal stance with regard to alcohol consumption. I contended in that post that there is little basis for this stance. Nevertheless, many members of the public are taking this very seriously, and “mainstream media is creating a negative narrative about wine with click-bait headlines that can impact government policy as well as popular opinion and consumption for years to come” (Come Over October: creating a positive narrative about wine).

One wine-industry response to this has been the increased development of low-alcohol and no-alcohol wines (sometimes called No-Lo wines). This is thus a topic worth looking at here, because there is little historically acquired expertise for this process (see my earlier post: Low- and no-alcohol wines really do need to be the way of the future).

World of Zero expo

It is particularly worth noting (Nolo: wine's final frontier) that:
“The rise of no or low-alcohol [Nolo] wines goes hand in hand with the increase of those seeking a healthier life. The benefits of a traditionally alcoholic beverage without alcohol are huge. For those with addiction issues or who are simply taking a break from alcohol, it can psychologically offer the placebo-like adult sophistication of an alcoholic beverage without the associated health risks.”
So, this is an issue that goes way beyond wine, or even alcohol in general, especially for younger generations (eg. Millennials drive no-alcohol gains in the US). Nevertheless, in this blog post I will restrict my comments to the making of the No-Lo wines themselves.

It has been argued (The war on wine) that: “Nonalcoholic wine is ... a gross contradiction in terms — and just kind of gross.” That is, wine contains alcohol by definition, so removing it creates a false terminology. More importantly, removing (or even reducing) the alcohol has a very big effect on the texture and taste of the resulting drink. Jeff Siegel (The war on wine) covers this topic in detail, as does an anonymous commenter (The idea of dealcoholised wine is appalling).

There three current methods (What is dealcoholized wine?): vacuum distillation, reverse osmosis, and spinning cone. The first two require heating the grape juice to almost body temperature, to evaporate the unwanted components (ie. alcohol) — this does, indeed, sound like it would have a pretty serious effect on the wine. The third method is thus the most common, in which the liquid is sent down a vertical series of spinning cones — the spinning motion of the cones separates out the different components, including the alcohol.

Spinning cone

What is most interesting, however, for we consumers is what wine-makers are going to do to address this issue, of the changed nature of the resulting NoLo wine. It seems very unlikely that they will do nothing for their product (see: 8 reasons to get excited about the no-alcohol category). However, it has been noted (The challenges of making low/no alcohol wine) that:
“It was striking how different the wines were. Removing even the smallest amount of alcohol affects the flavour; removing a chunk of it fundamentally alters the wine, demonstrating just how much impact alcohol has on wine flavour.”
This, then, is the conundrum. A wine is usually treated as having five components: sweetness, acidity, tannin, alcohol and body. Removing the alcohol actually affects all five of these, not just the fourth one. Something needs to be done to replicate the body, mouth-feel and perceived warmth associated with the equivalent alcoholic wine (The 5 characteristics of non-alcoholic wine).

Given all of this, it should come as no great surprise what the response has been: Why a fine de-alcoholised wine starts with an ‘undrinkable’ base. That is, we already know that, for example, if we intend to age a wine, then we need to start with a wine that is nothing like the intended drinking product: “a young Bordeaux or Barolo, for example, is intended to age and evolve for 20 years or more, and it is simply not going to be delicious after three years, unless you enjoy an astringently tannic mouthful” (How to define a good wine? It’s complicated). [On the weekend, my wife and I had a 2011 Rioja, which was perfect.]

So, it is no wonder that reduced alcohol wines need a pretty different starting point from usual, if they are to be any good at the end. That is: “vacuum distillation does result in the loss of 60% of the wine’s aromas, and 20% of the base product’s volume, and hence the need to exaggerate the aromatic profile before the process begins.” You can read the above article for a specific example (Why a fine de-alcoholised wine starts with an ‘undrinkable’ base).

Zero bottle

Given this idea, we can now consider whether anyone has yet created what the wine media might consider acceptable, or even good. As one example, Dave McIntyre at the Washington Post, has  some suggestions: Even with the alcohol removed, these new wines are actually good.

More generally, it has been noted that Germany has been making non-alcoholic wines for more than a century (For the best nonalcoholic wines, look to Germany), and may thus have some pretty good examples of how to proceed.

Even here in Sweden there is progress. For example:
“Oddbird was started in 2013 by family therapist Moa Gürbüzer. After working with families struggling with alcohol-related problems, she saddled up and started Oddbird to create good wines without alcohol.”
I have tried a few of the wines, and they are perfectly acceptable (and are inexpensive).